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force; they also have implications for pharmaceutical treatments, aging, and prevalent chronic conditions such as metabolic syndrome, insulin resistance, and hypertension. Thus, advances in our understanding of hormones that impact anabolic catabolic processes have relevance for athletes and the general population, alike. Copyright © 2020 Kraemer, Ratamess, Hymer, Nindl and Fragala.Accumulating studies implicate that the metformin (MET)- and oligofructose (OFS)-altered gut microbiota may play roles in the improvement of type 2 diabe