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In this way, this design provides a telomeric G-overhang-specific eradication strategy based on a non-G-quadruplex targeting manner. At standard and large inocula, daptomycin plus fosfomycin or cloxacillin were bactericidal against 4/5 and 5/5 strains, correspondingly, while cloxacillin plus gentamicin had been bactericidal against 3/5 strains at standard inocula but against none at high inocula. Fosfomycin, cloxacillin, gentamicin and daptomycin MIC/MBCs associate