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We focus on both beneficial and adverse effects of sirtuins in the regulation of energetic, biosynthetic and toxicity barriers faced by cancer cells.For proper spacing or rapid dispersion, some migratory cells are guided by repulsive collisions with their neighbors. A new study reveals that a surprising intercellular coupling of leading edge actin networks forms the basis of mutual repulsion in Drosophila hemocytes.The journey from seedling to plant requires guidance in the dark to establish which directions the roots and shoots should grow
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