https://www.selleckchem.com/pr....oducts/3-deazaneplan
Stable heavy-isotope labeling is commonly used in quantitative proteomics. Several common techniques incorporate deuterium (2 H) as the heavy isotopic label using reductive amination with formaldehyde. Compared with alternatives, dimethyl labeling reagents are inexpensive and the labeling chemistry is simple and rapid. However, the substitution of hydrogen by deuterium can introduce subtle changes in peptides' polarities, leading to a shift in chromatographic retention times between deuterated and nondeuterated peptide
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