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Our results provide the knowledge base for optimization of antimonial drug treatments guiding the selection and/or design of targeted drug delivery systems that mediate intracellular drug accumulation and quantitatively portray the immune dynamics of therapeutic healing. Our results provide the knowledge base for optimization of antimonial drug treatments guiding the selection and/or design of targeted drug delivery systems that mediate intracellular drug accumulation and quantitatively portray the immune dynamics of therapeutic healing.