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Special importance is given to the total synthesis and the synthetic strategies intended therein, comprising a set of main reactions. © 2020 Elsevier Inc. All rights reserved.The Amaryllidaceae alkaloids are a distinctive chemotaxonomic feature of the subfamily Amaryllidoideae of the family Amaryllidaceae, which consists of 59 genera and 800 species distributed primarily in tropical and subtropical areas. Since the first isolation, ca. 140 ago, 600 structurally diverse Amaryllidaceae alkaloids have been reported from ca. 350 speci