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mice) mice in this study. A549 cells and primary type II alveolar epithelial (ATII) cells had been treated with siRNA to cut back Ager gene expression. Autophagy had been inhibited by 3-methyladenine (3-MA). Lung injury had been examined by histopathological examination. Cell viability ended up being projected by cell counting kit-8 (CCK-8) assay. The serum and bronchoalveolar lavage fluid (BALF) degrees of interleukin (IL)-6, IL-8 and dissolvable TREND (sRAGE) had been evaluate