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Approximately 41% of 109 species will face extinction risks from climate change; the losing habitat areas in future climate condition will cause the varying of coniferous forest composition and the losing of ecosystem service related to the species; the uncertainty of losing distribution areas for species should not be ignored.PURPOSE We postulate that the deoxyguanosine analogue CNDAG [9-(2-C-cyano-2-deoxy-1-β-D-arabino-pentofuranosyl)guanine] likely causes a single-strand break after incorporation into DNA, similar to the action of its