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We focused on the neurogenesis category, which includes four genes for candidate markers choline acetyltransferase (ChAT) gene, β -adrenergic receptor (Adrb3) gene, and corticotrophin-releasing hormone (Crh) gene, and tryptophan 2,3-dioxygenase (Tdo2) gene. Real-time PCR showed a marked overexpression of ChAT, Adrb3, and Crh genes, while reduced expression of Tdo2. Western blot analysis also confirmed increased ChAT and decreased Tdo2 protein levels. We found that GEF affects mouse hippocampal gene expressions, associated with memory, co