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008] and 2.9 [95%CI 1.1-7.7, p = 0.03], respectively). In Crohn's disease, EIM were associated with an increased relapse rate (1.3 [95%CI 1.1-1.5], p = 0.001). Lastly, we found a positive temporal relationship between relapse of IBD and EIM activity. CONCLUSION The presence of EIM is associated with a more severe disease course in pIBD. This should be considered when deciding treatment options, as a more aggressive treatment approach could be warranted in patients with EIM. However, prospective studies are needed to fully evaluate this.
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