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Whilst the deregulation associated with the Hedgehog path is commonly observed in BCC, SCC and MCC tend to be described as a strikingly increased mutational and neoantigen burden. As outcome of our improved comprehension of the biology of non-melanoma skin cancers, revolutionary treatments including inhibitors associated with the Hedgehog path and immunotherapeutic representatives have now been recently investigated against these malignancies, resulting in their
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