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Modeling the impact of mass campaigns with M72/AS01 E and other fast-follower vaccine candidates will be crucial to make the use case and demonstrate public health value for TB endemic countries. The size and scope of the next generation of efficacy trials, and the need to expand and accelerate the existing clinical development pipeline, will require public and private consortium funding and concerted political will. Copyright © 2020 Hatherill, White and Hawn.Imbalance of Th1 and Th2 response at the maternal-fetal interface is considered
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