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ed by more high-quality clinical studies, especially prospective randomized controlled trials. Sleeve gastrectomy (SG) and one-anastomosis gastric bypass (OAG are among the commonly performed bariatric procedures. This randomized study aimed to compare SG and OAGB in terms of weight loss, improvement in comorbidities, and change in serum ghrelin and glucagon-like peptide-1 (GLP-1) levels. This was a prospective randomized trial on patients with morbid obesity associated with medical comorbidities who were randomly assigned to 1 of 2 e