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Arenaviruses, such as Lassa virus (LASV), can trigger severe and deadly hemorrhagic fevers (e.g., Lassa fever, LF) in humans without any vaccines or therapeutics. Analysis on arenavirus-induced hemorrhagic fevers (AHFs) happens to be hampered by the very virulent nature of the viral pathogens, which need high biocontainment laboratory, and also the not enough an immune-competent tiny animal design that may recapitulate AHF condition and pathological functions.