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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression People who suffer from untreated ADHD often suffer an inexplicably low level of performance, which can lead to feelings of despair and depression. This is particularly relevant when they fail to achieve their personal and professional objectives. Overlapping symptoms of comorbid ADHD and depression can make it difficult to determine a precise diagnosis. However, identifying the symptoms is the first step toward finding treatment. 1. Feelings of inadequacy Untrea