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These results strongly support 46 as a prototypical lead for the development of promising CXCR4 antagonists as clinical candidates.Ferric nitrosyl (FeNO6) and ferrous nitrosyl (FeNO7) complexes of the chlorite dismutases (Cld) from Klebsiella pneumoniae and Dechloromonas aromatica have been characterized using UV-visible absorbance and Soret-excited resonance Raman spectroscopy. Both of these Clds form kinetically stable FeNO6 complexes and they occupy a unique region of ν(Fe-NO)/ν(N-O) correlation space for proximal histidine liganded