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ADHD Treatment For Adults The stimulants like methylphenidate amphetamine, and other brain chemicals can aid in increasing levels. Nonstimulants, like antidepressants and atomoxetine, work slower than stimulants, but may also be helpful. Complicating conditions can alter the effectiveness of ADHD medications. The most severe symptom from any comorbidity should be treated first. Then, the physician should monitor whether ADHD symptoms improve. Medication Adults with ADHD are typically tr