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Adult ADHD and Comorbid Disorders Many people suffering from ADHD suffer from comorbid disorders, like major depression (Kessler and colleagues, 2006). Many depressed patients are not able to respond well to medication and may benefit from therapy. Medications that most effectively improve the most fundamental symptoms of ADHD are those that boost and balance levels of specific neurotransmitters, which are brain chemicals. Stimulants such as methylphenidate and amphetamine are often prescribed. Medicines Adults are able to take many differ