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SIPO- generated results were compared to data from treatments using the bronchorelaxant Isoproterenol (ISO). The study shows that SIPO in the range of 5 - 20 Hz induces relaxation in chronic sensitized airways, with significant improvements in respiratory parameters at SIPO values near 1.7 cmH2O irrespective of the frequency of generation.The first example of Ir(III)-catalyzed C-H activation/cyclization with N-alkoxyamides as amidation reagents to simultaneously form functionalized thiadiazine 1-oxide derivatives was develop

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