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The 2-wt.% composites showed no significant improvement in the compressive strength. The addition of 1-wt.% MWCNTs and TC nanomaterials can be considered in the future for enhancing the microstructure and compressive strength properties of pristine BioRoot™ RCS. The addition of 1-wt.% MWCNTs and TC nanomaterials can be considered in the future for enhancing the microstructure and compressive strength properties of pristine BioRoot™ RCS.Podoplanin (PDPN) plays a pivotal role in platelet aggregation, embryo development, and tumor progressi