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03 in patients receiving balanced salt solution. We also observed that the difference in serum sodium levels were significantly higher in patients receiving balanced salt solution as compared to those receiving 0.45% sodium chloride solution intraoperatively, at 3 h ( = 0.02) and at the end of surgery ( = 0.04) although the values were comparable in both the groups as measured on POD 0, 1 and 2. 0.45% sodium chloride solution has better effect on serum osmolality than balanced salt solution in patients undergoing transcranial resection of