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Although higher level treatments such as high-dose methotrexate (HD-MTX) and specific agents being introduced, the prognosis of those patients stays poorer compared to those with other types of non-Hodgkin's lymphoma. Twelve cases of Chinese PCNSL were analyzed to detect their hereditary modifications making use of whole-exome sequencing (WES). We identified 448 prospective somatic single nucleotide variations (SNVs) with a median of 12 SNVs per PCNSL sample and 35 ti