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We conclude with best practices for the implementation of these additions to realize conservation and agricultural benefits.Ppara-null and PPARA-humanized mice are refractory to hepatocarcinogenesis caused by the peroxisome proliferator-activated receptor-α (PPARα) agonist Wy-14,643. However, the duration of these earlier studies was limited to approximately one year of treatment, and the ligand used has higher affinity for the mouse PPARα compared to the human PPARα. Thus, the present study examined the effect of long-term administrati
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