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Implants with hybrid (H) and completely rough (R) area designs were utilized. Medical and radiographic variables were taped at 4 timepoints. Peri-implant sulcus substance ended up being collected from the buccal and lingual areas of the implants. The clear presence of 7 bacterial types and 2 host-derived biomarkers ended up being considered through the study duration. Total microbial counts had been significantly correlated with marginal bone loss (MBL) (r=.21; P=.009