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In locally advanced rectal cancer, radiotherapy (RT) followed by surgery have improved locoregional control, but distant recurrences remain frequent. Although checkpoint inhibitors have demonstrated objective response in several cancers, the clinical benefit of PD-1/PD-L1 blockade remains uncertain in rectal cancer. We collected data from biopsies and surgical specimens in 74 patients. The main objective was to evaluate the impact of neoadjuvant RT and fractionation on PD-L1 expression. Secondary objectives were to study

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It entails gentle, lengthy, kneading strokes, as nicely as mild, rhythmic, tapping strokes, on topmost layers of muscle tissue. By relieving muscle rigidity, Swedish therapy could be both relaxing and energizing. Paired with a 60-minute Signature Massage, this hot stone treatment incorporates heated, clean stones to chill out and soothe tense muscular tissues on key factors of the physique. The heat from the stones enhances the therapeutic effects, promoting muscle relaxation, improved circulation, and an general sense of tranquility. During a scorching stone t