https://www.selleckchem.com/pr....oducts/cloperastine-
Based on structural virtual screening, over one million compounds against the active pocket of caspase-1 were screened with molecular docking approaches. We yielded CZL80, a brain-penetrable small molecule caspase-1, which dramatically reduced neuronal excitability, incidence of FS generation, and relieved later enhanced epileptogenic susceptibility in adult. It was devoid of acute diazepam-like respiratory depression and chronic liver toxicity. CONCLUSION AND IMPLICATIONS These findings support that caspase-1 is crucial
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