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ADHD Medication UK For Adults The first prescription medication is typically an stimulant, such as methylphenidate. It increases activity in parts of the brain that control the behavior and attention. with ADHD are more likely to benefit from longer-acting formulations. They build up slowly in the bloodstream, thus avoiding the "crash" that can occur when short-acting medication wears off. Stimulants Stimulants are the most frequently prescribed medications for AD