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A number of aspects involve in bladder disease development such as for instance lifestyle and medicines. But, it appears that hereditary facets perform a substantial role in kidney cancer tumors development and progression. Phosphatase and tensin homolog (PTEN) is a cancer-related transcription factor that is corelated with minimal proliferation and invasion of disease cells by negatively concentrating on PI3K/Akt/mTOR signaling pathway. In the present analysis, we aimed to explore the part of PTEN in k