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The aim of the current study was to evaluate the performance of compressed SENSE (CS) for 3D amide proton transfer weighted (APTw) brain tumor imaging with different acceleration factors (AFs), and the results were compared with those of conventional SENSE. Approximately 51 patients with brain tumor (22 males, 49.95 ± 10.52 years) with meningiomas ( = 16), metastases ( = 12), or gliomas ( = 23) were enrolled. All the patients received 3D APTw imaging scans on a 3.0 T scanner with acceleration by CS (AFs CS2, CS3, CS4, and CS5) and SENSE (