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Bone tissue formation in critical-size defects in rats' cranial had been considered histologically and radiographically. The outcomes verified the effective fabrication of the hydrogel and its particular osteogenic induction ability on hDPSCs. Furthermore, in in vivo period, bone tissue development was notably greater in ADCNCs/SF/PEEK group. Thus, the enhanced bone regeneration as a result to PEEK-loaded hydrogels recommended its potential for regenerating bone tissue loss in th