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Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and RNA export. If these processes are not properly controlled, the nascent RNA can thread back and hybridize to the DNA template forming R-loops capable of stalling replication, leading to DNA breaks. Given the transcriptional promiscuity of the genome, which leads to large amounts of RNAs from mRNAs to different types of ncRNAs, these can become a major threat to genome integrity if they form R-loops. Consequently, cel

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Bifold Door Repair - How to Fix a Sticky Bifold Door If your bifold doors stick rather than smoothly open and close, the problem can be solved with some easy steps. Here's how. Adding carpet or changing the flooring material frequently causes bifold closet doors to scratch the floor. The bottom pivot adjustment can be used to raise the door. A little maintenance is also required to ensure that the hardware is free of dirt, debris, and dust. Versatility Bifold doors can be a gr