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With the prolongation of osteogenic induction, the mineralized nodules in the experimental group gradually increased. Silencing the P75NTR gene with siRNA lentivirus can promote the osteogenic differentiation of rat BMSCs and provide a new idea for the treatment of bone defects. Silencing the P75NTR gene with siRNA lentivirus can promote the osteogenic differentiation of rat BMSCs and provide a new idea for the treatment of bone defects. To investigate the effect of graphene oxide (GO)-carboxymethyl chitosan (CMC) hydrogel loaded with