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Increasing evidence uncover the essential role of lncRNAs in bone metabolism and the association of lncRNA with genetic risk of osteoporosis. However, whether lncRNA Neat1 is involved remains largely unknown. In the present study, we found that Neat1 is induced by osteoclastic differentiation stimuli. Knockdown of Neat1 attenuates osteoclast formation whereas overexpression of Neat1 accelerates osteoclast formation. In vivo evidence demonstrated that enhanced Neat1 expression stimulates osteoclastogenesis and reduces bone mass in mice.

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Home improvement is such a broad subject. Because it offers such a wide array of options, home improvement can seem a bit daunting and overwhelming. Most people may think they need a contractor to do these seemingly time consuming, impossible tasks. The thing is: you can do it yourself! This article focuses on teaching you how to complete simple, everyday home improvements by yourself, no contractor necessary. Before know it, you wi

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You should never want your home improvement project to leave you with an unsteady house because of poor work. That's why it's crucial you are aware of what to do prior to beginning a project. This article contains the knowledge you have to have to be a great handyman. Gardens add to the overall beauty of your home. Consider upgrading or adding one to your resid