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Gadolinium-based contrast agents (GBCAs) are considered to be safe, although sometimes patients report a hypersensitivity reaction when undergoing magnetic resonance imaging (MRI). The mechanisms of these reactions and of the sensitization to GBCAs are still largely unknown. We describe four cases of patients who experienced immediate adverse reactions to GBCAs with a demonstrated cutaneous hypersensitivity suggesting an IgE-mediated mechanism. Microsatellite instability (MSI) and circulating tumor cells (CTCs) play important roles in

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The Benefits of a Double Mattress A good mattress is crucial to a peaceful night's rest that promotes overall health and enhanced productivity. Double mattresses are designed to give couples plenty of space and comfort. Flipping two-sided mattresses regularly will improve weight distribution and minimize body impressions. This extends the lifespan of your mattress. Size While double mattresses are the most common choice for couples, it also has many advantages for single sl