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To determine the variations in the lasting medical effects between Regeneration (REG) and conventional procedure (CS) in infra-bony problems. Three databases were searched [PubMed, Medline and Embase] up to April 2019. Following evaluating, 17 scientific studies were included. Randomized Controlled Clinical Trials, Controlled Clinical studies and retrospective studies with long-lasting medical observations (≥ 24-months) had been selected. After subgrouping the studies concerning the grafti