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Injury prevention should include early DSs screening and monitoring and help adolescents and their neighborhood be aware of the risk. DSs strongly increase the injury risk in early adolescents. Injury prevention should include DSs screening and monitoring and help adolescents and their neighborhood be aware of the risk.HighlightsInjuries and depressive symptoms (DSs) are frequent in early adolescents.DSs highly predict subsequent school and out-of-school injuries and cumulating several injury types.These results are robust after adjust