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To evaluate clinical features of patients who first present with orbital symptoms and signs due to undiagnosed sinonasal pathology. Retrospective chart review for patients seen at Moorfields Eye Hospital between 1969 and 2020. Patient demographics and clinical features were reviewed. Four hundred and forty-eight patients (250 males; 56%) presented to ophthalmologists with undiagnosed sinonasal pathologies, the patients attending at an average age of 47 years and having first symptoms at an average age of 46 years. The commonest present

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To describe a potential case of pentosan polysulfate maculopathy that appeared to manifest nearly three years after drug cessation. Complete ophthalmic examination including multimodal fundus imaging, electroretinography, automated perimetry, and molecular testing were performed. A 44-year-old female with a 435g cumulative exposure to pentosan polysulfate sodium presented 38-months after drug cessation with six months of worsening metamorphopsia and prolonged dark adaptation. Fundus exam and multimodal fundus imaging demonstrated character