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In vivo, 12e showed similar antitumor efficacy to FL118 but lower toxicity. Our findings indicate that 12e is a promising therapeutic agent for cancer treatment, and the core structure of FL118 represents a promising platform to generate novel FL118-based antitumor drugs.Although emissions have a direct impact on air pollution, meteorological processes may influence inmission concentration, with the only way to control air pollution being through the rates emitted. This paper presents the close relationship between air pollution and met