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The study of this novel signaling axis may provide mechanistic insights into the neural regulation of colon cancer and help in the design of future clinical studies on stress biology in colorectal cancer. © 2020 The Authors. Published by FEBS Press and John Wiley Sons Ltd.Controllable tuning autophagy is an attractive target for cancer therapy, however, it remains difficult and challenging. We report herein pyridinium-substituted tetraphenylethylene salts PTPE 1 - 3 which can target mitochondria and induce autophagy after forming
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