https://www.selleckchem.com/pr....oducts/bay-2416964.h
The loss of cell viability in A2780 tumor cells was observed in the order Cu(Cl2-L1)NO3 Cu(Cl2-L1)Cl Cu(Br2-L1)Cl Cu(BrCl-L1)Cl. All complexes were able to induce reactive oxygen species (ROS) that could be related to the loss of cell viability. Complexes Cu(BrCl-L1)Cl and Cu(Cl2-L1)NO3 were able to promote A2780 cell apoptosis and autophagy and for complex Cu(BrCl-L1)Cl the increase in apoptosis was due to the intrinsic pathway. Cu(Cl2-L1)Cl and Cu(Br2-L1)Cl complexes lead to cellular detachment allowing to correlate
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