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Among serum proteins, bone-specific alkaline phosphatase, indicative of active mineralization, was greater in 5 MG than control (p less then 0.05). Sclerostin, an inhibitor of osteogenesis, was lower in 5 MG than control (p less then 0.05), also suggestive of enhanced healing. Conclusions An increase in bone volume, tissue volume and cellular signaling for osteogenesis at 17 days following fibula fracture in this mouse model suggests that gastrolith treatment holds potential for improving fracture healing. Further study at subsequent t
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