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r those less than 2.5 mm. Non-responding small-medium tumors multiply by 6 the probability of failure in local control. Lung cancer accounts for half of all deaths from cancer in Europe and has the highest incidence in Southern Europe. The current study aimed to cluster trend changes of lung cancer incidence in Europe via the growth mixture model. The dataset included incidence rates of female and male lung cancer per 100,000 for 42 European countries during 1990-2016 compiled from the Gapminder database. The growth mixture model was i