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Functional endpoint was good outcome defined as modified Rankin Scale (mRS) scores 0-3 at day 90. One hundred eleven patients were included. The median core lesion volume was 71 ml (IQR 25-107), and the median quantitative NWU was 9.5% (IQR 6-13). Relative CBV (rCBV) reduction and ASPECTS at baseline were independently associated with NWU in multivariable linear regression analysis (ß 12.4, 95%CI 6.0-18.9, p  50 ml (OR 0.16, 95% CI 0.05-0.49, p = 0.001). Our study shows that rCBV reduction serves as an early surrogate for increase of NW