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Developing a universal and simple structure with an excellent fluorescence enhancement is a highly desirable goal for practical applications in optical detection and imaging. Herein, a hybrid structure composed of melamine-formaldehyde (MF) microspheres covering an Au nanorod (AuNR) film (MS/AuNR for short) is reported to enhance fluorescence, which is based on the cooperative effects of a photonic nanojet and plasmon resonance. Moreover, to obtain an excellent plasmonic property, an additional poly(methyl methacrylate) (PMM

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