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In vivo evaluations demonstrated no detectable CPD after three consecutive daily 15s UVC exposures, whereas a single 300s exposure induced extensive CPD formation in superficial corneal epithelium. Up to three daily doses of 15s UVC, in vivo, appear safe with respect to CPD formation. Ongoing research exploring UVC as a possible treatment for microbial keratitis is warranted. Up to three daily doses of 15 s UVC, in vivo, appear safe with respect to CPD formation. Ongoing research exploring UVC as a possible treatment for microbial kerat