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Previous studies have demonstrated that dietary therapy can delay the initiation of dialysis, but little research has investigated whether patients with very poor renal function would benefit from a dietary therapy. This study was performed by using the Chang Gung Research Database (CGRD), which is based on the largest medical system in Taiwan. Patients with estimated glomerular filtration rates (eGFR) 15 mL/min/1.73 m between 2001 and 2015 with more than 3 months of low-protein diet supplemented with ketoanalogues (sLPD) were extract